Laboratory of Genetics of Aging and Longevity

DNA is a gene carrier

The Laboratory of Genetics of Aging and Longevity appeared in the MIPT Life Sciences Center in March 2013 in connection with the signing of the Cooperation Agreement with the Buck Institute for Research on Aging (California, USA). The studying of the causes and mechanisms of aging on different levels of the living organisms organization and the development of biomedical issues for the regulation of this process are fundamental scientific problems. The understanding of the nature of the aging process will allow people to control over longevity, to develop the preventive measures against premature aging and development of aging-associated diseases.

The laboratory activity is aimed at the search of genetic, epigenetic and physiological mechanisms of aging and longevity as well as at the search of substances and gene-therapy interventions able to slow down the aging process, to increase longevity and stress resistance of organisms by the influence on pathologic gene networks.

Nowadays, the laboratory is the only laboratory in Russia, which fully focuses on biogerontology. The laboratory researches are based on classical methods of molecular and cellular biology, new generation sequencing, the methods of work with laboratory animals, bioinformatics and mathematic modelling.

Laboratory Services

Preparation of bachelors and postgraduate students in different spheres of biogerontology.

Forecasting and testing of heroprotective features of pharmacetical drugs

In silico scheme of the forecasting of heroprotective substances

Personnel

Professor Bryan Kennedy (the Buck Institute) and Aleksey Moskalev in the MIPT Life Sciences Systems

Aleksey Aleksandrovich Moskalev — the Head of the Laboratory, Doctor of Biological Sciences, Assistant Professor. The author of over 80 scientific works and books on biology and genetics of aging, genetics of longevity and radiation genetics. The organizator of the regular international conference on Genetics of Aging and Longevity. The consultant of international scientific funds, pharmaceutical companies, the expert of the Higher Attestation Commission of the Ministry of Education and Science of the Russian Federation and the European Research Committee. Member of the Editorial Board of international magazines: Biogerontology (Springer), Aging-US (Impact Journals), Frontiers in genetics (Frontiers), American & Russian Bioscience (Landes Bioscience), Cell Transplantology and Tissue Engineering.
Zhikrivetskaya Svetlana — Junior Research Associate, PhD student, has a master’s degree in molecular genetics, research the changes of stress gene expression in response to different stresses and different doses of stress in order to obtain the confirmation of the non-specific stress response theory and the role of stress in aging and hormesis. Other interests include analysis of geroprotective properties of various substances and participation in creation an interactive encyclopedia of aging.
Lashmanova Ekaterina — PhD student, received master's degree in Biology from Syktyvkar State University. In 2013, she was awarded a scholarship of the President of the Russian Federation, and in 2012 was the winner of the award of the Government of the Komi Republic in the field of scientific achievements. A focus of her work is studying the effects of potential geroprotectors on lifespan and stress resistance of Caenorhabditis elegans.
Chernyagina Elizabeth — PhD student, a graduate of the Department of Biological and Medical Physics of Biological and Medical, MIPT. Her scientific work is focused on developing a model of geroprotectors and an online system for prediction of substances’ geroprotective properties, which can significantly accelerate the process of geroprotectors’ identification among existing substances as well as modeling and development of new pharmaceuticals with geroprotective properties. She also organizes educational activities on genetics of aging and longevity.

Equipment

The laboratory uses the equipment of cell and genomic common use centers of the MIPT Life Sciences Center.

  1. Flow cytometer

  2. Laminar box

  3. Inverted fluorescence microscope

  4. Cryoreservoir with liquid nitrogen

  5. CO2 incubator

Current Projects

  1. Screening researches of new heroprotectors on Nematoda model Caenorhabditis elegans
  2. The confirmation of the heroprotective features of pharmaceutical drugs with the use of expression pattern on the model of human cells in vitro

    Cell culture

  3. Sequencing de novo and whole genome analysis of long-lived mammals
  4. The research of the cellular senescence mechanisms of long-lived mammals
  5. Bioinformational researches aimed at the forecasting of the heroprotective features of pharmaceutical drugs

The comparison of old and young cells on flow cytometer

The comparison of old and young cells by the microscope

Publications

  1. SeimI, FangX, XiongZ, LobanovAV, HuangZ, MaS, FengY, TuranovAA, ZhuY, LenzTL, GerashchenkoMV, FanD, HeeYimS, YaoX, JordanD, XiongY, MaY, LyapunovAN, ChenG, KulakovaOI, SunY, LeeSG, BronsonRT, MoskalevAA, SunyaevSR, ZhangG, KroghA, WangJ, GladyshevVN. Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii // Nat Commun. 2013;4:2212. doi: 10.1038/ncomms3212. http://www.nature.com/ncomms/2013/130820/ncomms3212/full/ncomms3212.html
  2. Danilov A, Shaposhnikov M, Plyusnina E, Kogan V, Fedichev P, Moskalev A. Selective anticancer agents suppress aging in Drosophila // Oncotarget. 2013 Sep;4(9):1507-26. http://pubmedcentralcanada.ca/pmcc/articles/PMC3824538/
  3. Moskalev AA, Aliper AM, Smit-McBride Z, Buzdin A, Zhavoronkov A. Genetics and epigenetics of aging and longevity // Cell Cycle. 2014 Apr 1;13(7):1063-77. doi: 10.4161/cc.28433 https://www.landesbioscience.com/journals/cc/2014CC5643.pdf
  4. Moskalev A, Shaposhnikov M, Snezhkina A, Kogan V, Plyusnina E, Peregudova D, Melnikova N, Uroshlev L, Mylnikov S, Dmitriev A, Plusnin S, Fedichev P, Kudryavtseva A. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation // PLoS One. 2014 Jan 24;9(1):e86051. doi: 10.1371/journal.pone.0086051 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0086051
  5. Shaposhnikov M, Latkin D, Plyusnina E, Shilova L, Danilov A, Popov S, Zhavoronkov A, Ovodov Y, Moskalev A. The effects of pectins on life span and stress resistance in Drosophila melanogaster // Biogerontology. 2014 Apr;15(2):113-27. doi: 10.1007/s10522-013-9484-x http://link.springer.com/content/pdf/10.1007%2Fs10522-013-9484-x.pdf
  6. Zhavoronkov A, Buzdin AA, Garazha AV, Borisov NM, Moskalev AA Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs // Front Genet V. 5, P. 49, 2014. DOI: 10.3389/fgene.2014.00049 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940060/
  7. Moskalev AA, Pasyukova EG. From theories of aging to anti-aging interventions // Front Genet. 2014 Aug 14;5:276. doi: 10.3389/fgene.2014.00276
    http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00276/full
  8. Bgatova N, Dubatolova T, Omelyanchuk L, Plyusnina E, Shaposhnikov M, Moskalev A. Gadd45 expression correlates with age dependent neurodegeneration in Drosophila melanogaster // Biogerontology, 2015. V. 16, N1, P. 53-61.
    http://link.springer.com/article/10.1007/s10522-014-9533-0
  9. Craig T, Smelick C, Tacutu R, Wuttke D, Wood SH, Stanley H, Janssens G, Savitskaya E, Moskalev A, Arking R, de Magalhaes JP. The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource // Nucleic Acids Res. 2015. V. 43, N D1, Pp. D873-D878.
    http://nar.oxfordjournals.org/content/early/2014/09/17/nar.gku843.abstract
  10. Alexey Moskalev, Mikhail Shaposhnikov, Ekaterina Plyusnina, Sergey Plyusnin, Olga Shostal, Alexander Aliper, Alex Zhavoronkov. Exhaustive data mining comparison of the effects of low doses of ionizing radiation, formaldehyde and dioxins // BMC Genomics 2014 15(Suppl 12):S5.
    http://www.biomedcentral.com/1471-2164/15/S12/S5
  11. He C., Tsuchiyama S.K., Nguyen Q.T., Plyusnina E.N., Terrill S.R., Sahibzada S., Patel B., Faulkner A.R., Shaposhnikov M.V., Tian R., Tsuchiya M., Kaeberlein M., Moskalev A.A., Kennedy B.K., Polymenis M. Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import // PLoS genetics. 2014. Vol. 10, N 12. P. e1004860.
    http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004860
  12. Aliper A.M., Csoka A.B., Buzdin A., Jetka T., Roumiantsev S., Moskalev A., Zhavoronkov A. Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells // Aging, 2014. - V. 7, N1. - P. 1-12.
    http://www.impactaging.com/papers/v7/n1/full/100717.html

Organized International Conferences

  1. Symposium LONGEVITY GENES, 20th IAGG World Congress of Gerontology and Geriatrics, 2013, June 23-27, Seoul, Korea http://www.iagg2013.org
  2. Biorad 2014, Syktyvkar, 2014 http://ib.komisc.ru/add/conf/biorad
  3. Genetics of aging and longevity 2014, April 6-10, Sochi, Russia www.aging-genes2014.com
  4. WorkShop «Translation Technologies of Life prolongation»http://pharmcluster.ru/events-bfks/1445-workshop-translyatsionnye-tekhnologii-prodleniya-zhizni.html
  5. Simposium «Biomedicine», Second international conference on radiation and dosimetry in various fields of research RAD2014 (Nis, Serbia, 2014) http://www.rad2014.elfak.rs
  6. 6. Simposium “Molecular and Cellular Technologies of the Genetic Proccesses”, the VI Vavilov Conference of the Genetics and Selectioners Society http://conf.nsc.ru/vogis2014
  7. PhystechMed http://conference.mipt.ru/conference/phystech-med-2014

Contact Information