MIPT Life Sciences Center
The laboratory deals with the analysis of pharmaceutical substances in biological tissues and liquids for studying pharmacokinetics and bioavailability of pharmaceutical substances as well as the key processes characterizing the pharmacokinetic profile of the compounds in living bodies - absorptions, distributions, metabolism and excretion. The main objects of analysis are such biomaterials as plasma, blood, cerebro-spinal fluid, homogenates of different organs and tissues of laboratory animals, and cell culture extracts.
Laboratory of genetics of aging and longevity
The Laboratory of Genetics of Aging and Longevity appeared in the MIPT Life Sciences Center in March 2013 in connection with the signing of the Cooperation Agreement with the Buck Institute for Research on Aging (California, USA). The studying of the causes and mechanisms of aging on different levels of the living organisms organization and the development of biomedical issues for the regulation of this process are fundamental scientific problems. The understanding of the nature of the aging process will allow people to control over longevity, to develop the preventive measures against premature aging and development of aging-associated diseases.
The laboratory activity is aimed at the search of genetic, epigenetic and physiological mechanisms of aging and longevity as well as at the search of substances and gene-therapy interventions able to slow down the aging process, to increase longevity and stress resistance of organisms by the influence on pathologic gene networks.
Nowadays, the laboratory is the only laboratory in Russia, which fully focuses on biogerontology. The laboratory researches are based on classical methods of molecular and cellular biology, new generation sequencing, the methods of work with laboratory animals, bioinformatics and mathematic modelling.
Drug dosage forms design laboratory
The Drug Dosage Form Design Laboratory was founded in April 2013. The laboratory investigations are aimed at the creation of dosage forms with modified release of pharmaceutical substances.
The Objectives of the Drug Dosage Form Design Laboratory:
- The researches of the features of pharmaceutical substances with the aim to create more effective and safe pharmaceutical drugs
- Research and development of the delivery systems increasing the efficiency and safety of the use of pharmaceutical substances
- Research and development of pharmaceutical forms with the modified release of pharmaceutical substances
Laboratory for innovative drug products
The development of the Laboratory for the Development of Innovative Pharmaceutical Drugs in the MIPT Life Sciences Center is connected with the name of the 2001 Nobel laureate in chemistry Barry Sharplesson, who visited MIPT in 2011 and offered to develop the validation of new approaches in the fundamental improvement of the quality of pharmaceutical drugs that affect the biological and metabolic processes in the cell. These new methods are based on the use of innovative click-chemistry, which is used for testing on different cellular models, including carcinogenesis, inflammation and Alzheimer's and Parkinson's diseases.
Laboratory of sequencing and mathematical modeling of the transcriptome
Laboratory of sequencing and mathematical modelling of the transcriptome was established at the MIPT in 2011 and is now part of the the MIPT Life Sciences Center. Since 2013, the main project of the laboratory has become the development of the system for the diagnostics of rare Mendelian disorders with a usage of the massive parallel sequencing technologies. The work is carried out under the State Contract of the Ministry of Industry and Trade of the Russian Federation No. 13411.1008799.13.086 for the performance of research and development work “The development of technology and production organization of the analysis system of genetic diseases with the use of massively parallel sequencing”.
The test-system of rare Mendelian disorders with the use of next-generation sequencing (NGS) technologies, developed in the laboratory, is designed to diagnose over 60 diseases by detecting up to 1500 of the known mutations in more than 60 genes. Nowadays, as a result of the joint work of medical geneticists, molecular biologists and bioinformaticians, the socially significant monogenic hereditary diseases caused by single-nucleotide substitutions, short insertions and deletions were selected,the database of the mutations associated with the most common hereditary diseases was created, and the algorithms for the analysis of DNA sequences were implemented. The primer panel for targeted amplification of genes associated with 60 hereditary diseases (about 450 pairs of primers) was developed and partially tested. The work on the creation of the forecasting system of the effect of mutations on the structural and functional properties of proteins encoded by the genes, in which mutations cause rare diseases, is also being carried out.
The diagnostics test-system focusing on the screening of genetic defects associated with hereditary diseases that was created in the laboratory, is the first of its kindin Russia.
Laboratory of medical instrumentation engineering
The main directions of applied researches:
- Spectral methods for measuring regional oximetry
- Low inertia sensors design for respiratory parameters measuring systems and end user equipment modeling and design
- Modeling and design of the systems and the end equipment for personal telehealth
- Automatic analysis of biomedical signals for smart devices and medical decision-making support systems
- Therapeutic effect individualization by the identification and evaluation of the side effects dynamics of pharmaceutical drugs
Systems biology laboratory
The Laboratory of systems biology conducts the researches in the sphere of the problems of data integration of transcriptional, proteomic and metabolic activity of the genome of biological objects. In the research projects carried out in the sphere of post-genomic biology and medicine, not only information about the complete DNA sequence of the studied object is used, but also the persistence of the genome is studied, its micro- and macroheterogeneity is described as well as cause-and-effect relationships that occur in case of the DNA instability on the level of matrix RNA and proteins.
A key condition of the systems biology projects is a creation of a technological complex of methods, the so-called technological platform, which will allow to carry out researches at four levels of the cell organization, i.e. to define the stability parameters of the genome of the studied object (full genome sequencing), to determine the level of gene transcription (transcription profile), to measure the proteins expression and their post-translational modification (proteomic profile), as well as to register the flows of metabolites.
The Laboratory was founded in 2013 as a part of the MIPT Life Sciences Center for the research of omix human data for the needs of medicine, biotechnological industry, knowledge generation in the field of life sciences, and for the search of new drug compounds.
Laboratory of translational research and personalized medicine
The Laboratory of Translational Research and Personalized Medicine was founded in April 2013. The laboratory activity is focused on the scientific researches in the field of personalized oncology, on the implementation of the scientific results into the product development, as well as on the educational activity. Moreover, the laboratory is focused on the study of cause-and-effect relationships between the mutations and changes in the tumor expression profiles, as well as the phenotypic manifestation of these changes; the study of the resistance mechanisms to the antitumoral pharmaceutical drugs.
The laboratory develops a clinical and diagnostic platform for the personalized selection of the most effective cancer treatment, which has no analogues in the world. During the project implementation, a diagnostic platform will be developed and introduced into clinical practice, which will allow doctors to prescribe the most effective therapy taking into consideration the individual characteristics of each patient based on genetic and expression biomarkers.
Laboratory of medicinal chemistry and bioinformatics
The design of focused and thematic libraries of organic compounds. Projects on the synthesis and testing of new compounds, the development of specialized software in the field of medicinal chemistry, nanotechnology and agricultural chemistry.
(The Head is Y.A. Ivanenkov)
Laboratory of scientific technical analysis and prognosis
Analytical studies on development status of scientific directions and approaches in biomedical and pharmaceutical technologies and their use for development of new drug products, diagnostic tools.
(The Head is K.V. Balakin)
Biomedical engineering laboratory
The development of tissue-engineered bioconstructions with specified organ or tissue-substituting functions.
(The Head is V.Y. Abramov)
Laboratory of simulation of biological systems
The development and design of the complicated biological systems for the evaluation of the effectiveness of pharmaceutical drugs and for the study of fundamental mechanisms of component interaction of such systems.
(The Head is P.O.Fedichev)
The study of the formation of rhythm, arrhythmia and fibrillation of the heart, the dynamics of vortex autowave structures by the method of computer simulation.
(The Head is A.I. Efimov)
Laboratory for chemical synthesis and catalysis
РThe development of new catalytic transformations and their application in fundamental researches of biomarkers on the early stages of inflammation, cancer and autoimmune diseases.
(The Head is V.V. Fokin)
Agricultural biotechnology laboratory
The search for new effective plant growth modulators with the use of the modern technologies of high-efficiency phenotypic screening.(The Head is A. Turaev)
Laboratory for personalized genomic diagnostic and genetic therapy
The validation and introduction into clinical practice of genetic, matabolic and proteomic tests.
(The Head is T.O. Amirova)
Laboratory of historical genetics, radiocarbon analysis and applied physics
The study of human genome history. The development of physical chronology methods including accelerator mass-spectrometry.
(The Head is Kh.Kh. Mustafin)
Laboratory of biophysics of excitable system
The creation of artificial cardiac tissue patches, with a focus on portions of the heart suitable for implantation and damage replacement. The study of the processes that lead to dangerous cardiac arrhythmias.
(The Head is K.I. Agladze)
Laboratory of government programms and development projects in life sciences
The development of teh development projects in the sphere of “life sciences” and strategic consulting in the sphere of biomedical technologies.
(The Head is O.M. Korzinov)
Laboratory of pre-clinical researches
(The Head is Alekseev S.G.)